HBV Translational Research: Solving Complex Problems Through a Multidisciplinary Approach

"Dahari Lab is committed to the WHO goal of global viral hepatitis elimination"

Despite an effective vaccine, hepatitis B virus (HBV) remains a growing health concern and burden on systems. Hundreds of millions globally are infected. The virus in adults will typically be an acute infection but for children and infants, the rate of HBV as a chronic infection can be as high as 90%. This presents a serious health issue for the patient and strains healthcare resources. Additionally, HBV carries are at risk of co-infection with hepatitis D which is more aggressive in its attack on the liver. Previous research was limited by lack of in vitro cultures and small animal models to study both the infection and treatment. Now we are able to observe the HBV lifecycle and treatment response in cell cultures as well as mice. This will lead to a better understanding of the virus at the molecular level and is critical to developing more effective treatment strategies. Mathematical modelling has played a key role in filling previous clinical gaps and will deepen our understanding as the research evolves. The goal is to map and understand the detailed molecular biological processes that regulate HBV infection. In Dahari Lab we work with a cross disciplinary team of virologists, animal modeling experts, computational scientists, clinicians and pharmaceutical companies, we aim to better understand the virus-host interplay, the mode of actions of current and new antivirals, and treatment strategies. All of this is possible with more sophisticated models and is key to achieving a cure.

 

 

 

 

 

Click here for the full extent of our lab's research!

Research Topics

Location and Hours


We can be reached by phone 24 hours a day at 1.403.343.1619 or by email at info@pregnancycare.ca during office hours.




Red Deer


5116 47 St, Red Deer, AB T4N 1R9 info@pregnancycare.ca 24 Hour Helpline: 1-844-343-1611 Office: 1-403-343-1611 Monday: 9am – 5pm
Tuesday: 9am – 5pm
Wednesday: 9am – 8pm
Thursday: 9am – 5pm
Friday: Closed
Weekends: Closed Follow us on FACEBOOK




Olds


4911-51 Ave, Olds, Alberta T4H 1P7
olds@pregnancycare.ca
24 Hour Helpline: 1-844-343-1611 Office: 1-587-796-1611 Tuesday: 10am – 5pm
Wednesday: 10am – 5pm
5pm – 8pm by appointment only
Thursday: 10am – 5pm Follow us on FACEBOOK




Rocky Mountain House


4704 46 St, Rocky Mountain House, AB
rmh@pregnancycare.ca
24 Hour Helpline: 1-844-343-1611 Office: 1-403-871-5111 Monday: 10am – 6pm
Thursday: 10am – 6pm Follow us on FACEBOOK




Drumheller


drumheller@pregnancycare.ca 24 Hour Helpline: 1-844-343-1611 Office: 1-403-334-9311 Tuesday: 10am - 5pm Thursday: 10am - 5pm Follow us on FACEBOOK




Caroline


Bay #2, 5040 49 Ave, Caroline, AB
caroline@pregnancycare.ca
24 Hour Helpline: 1-844-343-1611 Office: 1-403-871-5111 Tuesday: 12pm – 4pm By appointment only Follow us on FACEBOOK





Partnerships that get results: Global. Fluid. Connected. Join Us!

Loyola University Medical Center

Department of Medicine

Division of Hepatology

2160 S. First Ave
Mulcahy Center, Rm 1610

Maywood, IL 60153, USA

Email: hdahari@luc.edu

Phone: 708-216-4682

Fax: 708-216-6299