Rapid monophasic hepatitis B surface antigen decline during nucleic-acid polymers-based therapy predicts functional cure

 

The study (Hepatology Comms.) aimed to identify kinetic patterns associated with functional cure in HBeAg-negative chronic hepatitis B patients receiving nucleic-acid polymers (NAPs)-based therapy. Functional cure was associated with a rapid monophasic decline in HBsAg during NAP-based therapy, while non-monophasic HBsAg-kinetic patterns had a 100% negative-predictive value for functional cure. The study suggests that monitoring HBsAg kinetic patterns during NAP-based therapy may provide useful information for predicting treatment outcomes.