Highlights HCV research with Dr. Charles Rice, 2020 Nobel Prize recipient. (2004-2007) Our (2004-2007) HCV research with Dr. Charles Rice, 2020 Nobel Prize recipient contributed to the following translational research which deepened knowledge of the HCV-host dynamic on the molecular level and during acute infection in chimpanzees. Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees (2004) Mathematical modeling of primary hepatitis C infection: noncytolytic clearance and early blockage of virion production (2005) Mathematical modeling of subgenomic hepatitis C virus replication in Huh-7 cells. (2007) Large Scale RGT Clinical Trial Preview October 2020 Success in real-time patient therapy to be tested in larger HCV treatment clinical trial with Israeli research partners. Significant implications for healthcare cost, duration of treatment and patient-care. Harel Dahari's recent work was acknowledge at a conference in South Korea. Publication; Press Release; Conference Ultrashort HCV Time-to-Cure Results May 2020 Proof-of-concept HCV study yields promising results for a 4-week ultra-short, response-guided therapy treatment. Retrospective modeling of viral kinetics underscores the potential usefulness of a personalized modeling-based RGT approach to shorten the duration of treatment. Publication Promising Results for Transplant Recipients May 2020 Therapy combination prevents HCV infection in organ transplant recipient. Anti-viral treatment optimization results in milestone achievement in collaboration with Canadian cohort. For the patient, this results in cheaper, safer treatments, and removes the added risk of HCV while in post-transplant recovery [AASLD]. This comes at a time when HCV infection and mortality rates in younger populations are on the rise due to the ongoing opioid crisis [CDC]. Publication; Press Release; Comment HBV/HDV Research Advancement May 2020 Mathematical modeling leads to new insights in HBV/HDV research with biopharma firm Replicor. Defining Mode of Action helped unlock promising new therapy in development for HBV treatment as well as in patients coinfected with HDV. Publication; Replicor Press Release Principles of Cell Circuits for Tissue Repair and Fibrosis February 2021 DahariLab hosted Miri Adler, PhD from The Broad Institute of MIT and Harvard to discuss her research on the social behavior of cells during tissue repair and fibrosis. As part of her research, Dr. Adler developed a mathematical model to better understand the principles of this dynamic. ReplyForward Add reaction

Our International Community: Dahari Lab believes that an international community of students, faculty, trainees, and staff promotes innovative research, increases quality of patient care, and provides the richest set of viewpoints for solving complex problems. Since its inception, we have invested in a global network of research partnerships from a variety of disciplines with diverse backgrounds and experiences. Lab Members Bangladesh Canada China Colombia Ethiopia France Germany India Ireland Israel Japan Philippines Russia USA Zimbabwe Partners Australia Austria Belgium Brazil Canada China Italy Japan France Germany Israel Spain Sweden Turkey USA

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