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Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments

Oren Shechter, Daniel G. Sausen, Elisa S. Gallo, Harel Dahari, and Ronen Borenstein

Journal of Molecular Sciences

November 2022

[Full Text, Pubmed]

Epstein–Barr virus (EBV) is one of eight known herpes viruses with the potential to infect humans. Globally, it is estimated that between 90–95% of the population has been infected with EBV. EBV is an oncogenic virus that has been strongly linked to various epithelial malignancies such as nasopharyngeal and gastric cancer. Recent evidence suggests a link between EBV and breast cancer. Additionally, there are other, rarer cancers with weaker evidence linking them to EBV. In this review, we discuss the currently known epithelial malignancies associated with EBV. Additionally, we discuss and establish which treatments and therapies are most recommended for each cancer associated with EBV.

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