A Mathematical Model for early HBV and -HDV Kinetics during Anti-HDV Treatment

Mathematics

 December 2021

[Full Text, Pubmed]

Abstract

Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.

Rami Zakh, Alexander Churkin, William Bietsch, Menachem Lachiany, Scott J. Cotler, Alexander Ploss, Harel Dahari, and Danny Barash