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Stress-Induced Epstein-Barr Virus Reactivation


September 2021

[Full Text, Pubmed]


Epstein-Barr virus (EBV) is typically found in a latent, asymptomatic state in immunocompetent individuals. Perturbations of the host immune system can stimulate viral reactivation. Furthermore, there are a myriad of EBV-associated illnesses including various cancers, post-transplant lymphoproliferative disease, and autoimmune conditions. A thorough understanding of this virus, and the interplay between stress and the immune system, is essential to establish effective treatment. This review will provide a summary of the interaction between both psychological and cellular stressors resulting in EBV reactivation. It will examine mechanisms by which EBV establishes and maintains latency and will conclude with a brief overview of vaccines targeting EBV.

Daniel G. Sausen, Maimoona S. Bhutta , Elisa S. Gallo, Harel Dahari  and Ronen Borenstein

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Loyola University Medical Center

Department of Medicine

Division of Hepatology

2160 S. First Ave
Mulcahy Center, Rm 1610

Maywood, IL 60153, USA


Phone: 708-216-4682

Fax: 708-216-6299

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